Interstate 29 At a Glance Distance: 320 miles Trip Length: 2 days Start/Stop: Sisseton or Vermillion Culture and nature exist in perfect harmony in eastern South Dakota. Take a zigzag route of detours off I-29, the state’s main north/south corridor, to see sculptures, gardens, museums, historical homes, state parks and other places of natural and manmade beauty. 28 // #HiFromSD Arc of Dreams