Set the Scene YOUR BACKDROP FOR VACATION DISCOVER AN ARRAY OF PICTURE-PERFECT LANDSCAPES ACROSS SOUTH CAROLINA: WATERFALLS AND FORESTS IN THE MOUNTAINS REGION, LAKES AND RIVERS IN THE MIDLANDS REGION AND WHITE-SAND BEACHES AND MOSS-DRAPED OAKS IN THE COASTAL REGION. FIND YOUR SCENE. Photo: The Midlands Region offers an abundance of rivers, lakes and reservoirs. As the largest lake in the state, Lake Marion in Santee is beloved by boaters and anglers for its big fish, abundant wildlife and easy public access points. 4